4. Metal–Organic Framework Nodes Support Single-Site Magnesium–Alkyl Catalysts for Hydroboration and Hydroamination Reactions

Kuntal Manna, Pengfei Ji (co-first), Francis X. Greene, and Wenbin Lin* 

Here we present the first example of a single-site main group catalyst stabilized by a metal–organic framework (MOF) for organic transformations. The straightforward metalation of the secondary building units of a Zr-MOF with Me₂Mg affords a highly active and reusable solid catalyst for hydroboration of carbonyls and imines and for hydroamination of aminopentenes. Impressively, the Mg-functionalized MOF displayed very high turnover numbers of up to 8.4 × 10⁴ for ketone hydroboration and could be reused more than 10 times. MOFs can thus be used to develop novel main group solid catalysts for sustainable chemical synthesis.